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Targeted nanoparticles

Through the integration of multidisciplinary approaches within medicinal chemistry and nanobiotechnology, Nanomater can design and build nanoparticles for "Active Targeting", with programmable features, in order enhance site-specificity towards different biological targets, as well as to increase the therapeutic efficacy and the bioavailability of active molecules.

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The nanoparticle surface can be functionalized with specific ligands (antibodies, peptides, aptamers or small organic molecules), which allow to increase the plasma half-life, reduce immunogenicity and favor the targeting toward surface proteins overexpressed on target cells.

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Nanomater can encapsulate molecules provided by the client and engineer or functionalize the nanoparticles according to specific requests

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R&D OF TARGETED NANOPARTICLES

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-structure-based design of ligand for targeting

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-polymer functionalization with ligand
 

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-targeted nanoparticles formulation

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-nanoparticles characterization
 

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-in vitro dissolution test

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- In vitro stability test

 

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-in vitro biocompatibility test

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- In vitro cytotoxicity test

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