Through the integration of multidisciplinary approaches within medicinal chemistry and nanobiotechnology, Nanomater can design and build nanoparticles for "Active Targeting", with programmable features, in order enhance site-specificity towards different biological targets, as well as to increase the therapeutic efficacy and the bioavailability of active molecules.
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The nanoparticle surface can be functionalized with specific ligands (antibodies, peptides, aptamers or small organic molecules), which allow to increase the plasma half-life, reduce immunogenicity and favor the targeting toward surface proteins overexpressed on target cells.
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Nanomater can encapsulate molecules provided by the client and engineer or functionalize the nanoparticles according to specific requests
R&D OF TARGETED NANOPARTICLES
-structure-based design of ligand for targeting
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-polymer functionalization with ligand
-targeted nanoparticles formulation
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-nanoparticles characterization
-in vitro dissolution test
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- In vitro stability test
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-in vitro biocompatibility test
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- In vitro cytotoxicity test
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